The Tennessee Titans lost their defensive coordinator in the first quarter and may have lost quarterback
Marcus Mariota left in the final minute of the first half against the Colts with an undisclosed injury.
Mariota was injured after being sacked by Denico Autry. He sat on the ground briefly before walking to the sideline and then to the locker room, even though the Titans were forced to use a timeout which would have allowed Mariota to stay in the game.
Backup Blaine Gabbert replaced Mariota and completed a six-yard pass on third-and-14. But an unnecessary roughness call on Indianapolis' George Odum moved the ball to the Colts 24 and set up
Ryan Succop for a 42-yard field goal to cut the Titans' deficit to 24-3.
Defensive coordinator Dean Pees was transported to an Indy hospital after leaving the press box in a wheelchair. The Titans later issued a statement saying he had left the stadium for further observation.
Tennessee came into the game with the league's top-ranked scoring defense.